A statistical view of protein chemical synthesis using NCL and extended methodologies.
Identifieur interne : 000392 ( Main/Exploration ); précédent : 000391; suivant : 000393A statistical view of protein chemical synthesis using NCL and extended methodologies.
Auteurs : Vangelis Agouridas [France] ; Ouafâa El Mahdi [Maroc] ; Marine Cargoët [France] ; Oleg Melnyk [France]Source :
- Bioorganic & medicinal chemistry [ 1464-3391 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- composition chimique : Benzimidazoles, Hydrazines, Peptides, Protéines, Thiols.
- métabolisme : Protéines.
- synthèse chimique : Peptides, Protéines.
- Bases de données factuelles.
English descriptors
- KwdEn :
- MESH :
- chemical , chemical synthesis : Peptides, Proteins.
- chemical , chemistry : Benzimidazoles, Hydrazines, Peptides, Proteins, Sulfhydryl Compounds.
- chemical , metabolism : Proteins.
- Databases, Factual.
Abstract
Native chemical ligation and extended methodologies are the most popular chemoselective reactions for protein chemical synthesis. Their combination with desulfurization techniques can give access to small or challenging proteins that are exploited in a large variety of research areas. In this report, we have conducted a statistical review of their use for protein chemical synthesis in order to provide a flavor of the recent trends and identify the most popular chemical tools used by protein chemists. To this end, a protein chemical synthesis (PCS) database (http://pcs-db.fr) was created by collecting a set of relevant data from more than 450 publications covering the period 1994-2017. A preliminary account of what this database tells us is presented in this report.
DOI: 10.1016/j.bmc.2017.05.050
PubMed: 28578993
Affiliations:
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Le document en format XML
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Lille, CNRS, Institut Pasteur de Lille, UMR 8161 - M3T - Mechanisms of Tumorigenesis and Target Therapies, F-59000 Lille, France. Electronic address: vangelis.agouridas@ibl.cnrs.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. 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Their combination with desulfurization techniques can give access to small or challenging proteins that are exploited in a large variety of research areas. In this report, we have conducted a statistical review of their use for protein chemical synthesis in order to provide a flavor of the recent trends and identify the most popular chemical tools used by protein chemists. To this end, a protein chemical synthesis (PCS) database (http://pcs-db.fr) was created by collecting a set of relevant data from more than 450 publications covering the period 1994-2017. A preliminary account of what this database tells us is presented in this report.</div></front></TEI><affiliations><list><country><li>France</li><li>Maroc</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="France"><region name="Hauts-de-France"><name sortKey="Agouridas, Vangelis" sort="Agouridas, Vangelis" uniqKey="Agouridas V" first="Vangelis" last="Agouridas">Vangelis Agouridas</name></region><name sortKey="Cargoet, Marine" sort="Cargoet, Marine" uniqKey="Cargoet M" first="Marine" last="Cargoët">Marine Cargoët</name><name sortKey="Melnyk, Oleg" sort="Melnyk, Oleg" uniqKey="Melnyk O" first="Oleg" last="Melnyk">Oleg Melnyk</name></country><country name="Maroc"><noRegion><name sortKey="El Mahdi, Ouafaa" sort="El Mahdi, Ouafaa" uniqKey="El Mahdi O" first="Ouafâa" last="El Mahdi">Ouafâa El Mahdi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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